Formation ofl-Glutamic Acid fromγ-Aminobutyric Acid by Plant Enzyme

Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67.

The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA receptor subunit develop a cleft secondary palate. GABA, the ligand for this receptor, is synthesize...

GAMMA-AMINOBUTYRIC ACID AND GLUTAMIC ACID IN HUNTINGTON'S DISEASE: INVESTIGATION OF NEUROTRANSMITTER RECEPTORS USING RADIOLABELED AGONISTS by-

3H-Muscimol, a structural analog of y-aminobutyric acid (GABA) , binds to rat brain synaptic membranes in a saturable manner, with a high affinity dissociation constant of 2.2 nM. Binding is increased in membranes that have been treated with Triton X-1Q0 and is not 3 dependent upon sodium. High affinity H-muscimol binding is regionally distributed, with highest binding density in the cerebellum...

Accumulation of freely extractable glutamic acid by lactic acid bacteria.

Gale (2, 3) initially described the existence in bacteria of a metabolism-dependent process achieving the accumulation of freely extractable amino acids. During the studies described here a number of additional reports have appeared citing examples of amino acid (4, 5), carbohydrate (6), and phosphate (7) accumulations in bacteria. The mechanism of these accumulations is unknown. Christensen et...

Determination of Glutamic Acid

y-aminobutyric acid

An enzyme which catalyses dehydrogenation of y-aminobutyraldehyde (ABAL) to y-aminobutyric acid (GABA) was purified to homogeneity from rat brain tissues by using DEAE-cellulose and affinity chromatography on 5'AMP-Sepharose, phosphocellulose and Blue Agarose, followed by gel filtration. Such an enzyme was first purified from mammalian brain tissues, and was identified as an isoenzyme of aldehy...